Hyperinsulinemia leads to increased vascular resistance in an isolated digit model

Dr Gauff from Austria and col. from UK have studied the effect of hyperinsulinemia on vascular resistance.

They conclude that with the insuline increase, there is a marked increase of vascular resistance and overexpression of endotelin 1. It is only an ex-vivo study, and more work needs to be done to extrapolate to in  vivo situation, but this is a step forward to try to explain the relationship between insuline and laminitis.
Here is the link to the paper:

https://www.dropbox.com/s/e1o7ape7rjtgnrh/evj12040-%20Hyperinsulinemia.pdf